Small-Molecule Disruptors of Mutant Huntingtin–Calmodulin Protein–Protein Interaction Attenuate Deleterious Effects of Mutant Huntingtin-Reference-Cited by-同舟云学术

Small-Molecule Disruptors of Mutant Huntingtin–Calmodulin Protein–Protein Interaction Attenuate Deleterious Effects of Mutant Huntingtin

Published:2022-07-14 Issue:15 Volume:13 Page:2315-2337
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Kapadia Khushboo¹,Trojniak Ashley E.²,Guzmán Rodríguez Kenneth B.²^ORCID,Klus Nicholas J.²,Huntley Coral³,McDonald Peter³^ORCID,Roy Anuradha³,Frankowski Kevin J.²^ORCID,Aubé Jeffrey²^ORCID,Muma Nancy A.¹^ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States

2. Division of Chemical Biology and Medicinal Chemistry, and the Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Eshelman School of Pharmacy, 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States

3. University of Kansas High-Throughput Screening Laboratory, University of Kansas, 2034 Becker Drive, Lawrence, Kansas 66047, United States

Funder

National Institute of Neurological Disorders and Stroke

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.2c00305

Reference37 articles.

1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

2. Huntingtin in health and disease