Structure-Based de Novo Design, Synthesis, and Biological Evaluation of Non-Azole Inhibitors Specific for Lanosterol 14α-Demethylase of Fungi-Reference-Cited by-同舟云学术

Structure-Based de Novo Design, Synthesis, and Biological Evaluation of Non-Azole Inhibitors Specific for Lanosterol 14α-Demethylase of Fungi

Published:2003-01-18 Issue:4 Volume:46 Page:474-485
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ji Haitao¹,Zhang Wannian¹,Zhang Min¹,Kudo Makiko¹,Aoyama Yuri¹,Yoshida Yuzo¹,Sheng Chunquan¹,Song Yunlong¹,Yang Song¹,Zhou Youjun¹,Lü Jiaguo¹,Zhu Jü¹

Affiliation:

1. School of Pharmacy and Department of Microbiology, Second Military Medical University, Shanghai 200433, China, School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya 663-8179, Japan, and Faculty of Engineering, Soka University, Hachioji, Tokyo 192-8577, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm020362c

Reference36 articles.

1. Sterol 14-Demethylase P450 (CYP51) Provides a Breakthrough for the Discussion on the Evolution of Cytochrome P450 Gene Superfamily

2. Cytochrome P450 (CYP) mutants and substrate-specificity alterations: segment-directed mutagenesis applied to human CYP IAI

3. Current and Emerging Azole Antifungal Agents

Cited by 110 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis and evaluation of 2-phenylpyrimidine derivatives as novel antifungal agents targeting CYP51;RSC Medicinal Chemistry;2024

2. Recent advances in antifungal drug development targeting lanosterol 14α‐demethylase (CYP51): A comprehensive review with structural and molecular insights;Chemical Biology & Drug Design;2023-05-23

3. Delineating Potential De Novo Therapeutics and Repurposed Drugs Against Novel Protein Lrrc15 to Treat Sars-Cov-2;Letters in Drug Design & Discovery;2023-02-23

4. Tetrahydro-β-carboline scaffold in drug discovery;Privileged Scaffolds in Drug Discovery;2023

5. A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective;European Journal of Medicinal Chemistry;2021-12