Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA-Reference-Cited by-同舟云学术

Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA

Published:2017-06-19 Issue:25 Volume:139 Page:8537-8546
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Schlegel Mark K.¹^ORCID,Foster Donald J.¹,Kel’in Alexander V.¹,Zlatev Ivan¹,Bisbe Anna¹,Jayaraman Muthusamy¹,Lackey Jeremy G.¹,Rajeev Kallanthottathil G.¹,Charissé Klaus¹,Harp Joel²,Pallan Pradeep S.²,Maier Martin A.¹,Egli Martin²,Manoharan Muthiah¹

Affiliation:

1. Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States

2. Vanderbilt University School of Medicine, Department of Biochemistry, Nashville, Tennessee 37232, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.7b02694

Reference50 articles.

1. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2. Structural insights into RNA processing by the human RISC-loading complex