Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient-Reference-Cited by-同舟云学术

Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Published:1999-12-10 Issue:3 Volume:4 Page:199-204
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Cheruvallath Zacharia S.¹,Carty Recaldo L.¹,Moore Max N.¹,Capaldi Daniel C.¹,Krotz Achim H.¹,Wheeler Patrick D.¹,Turney Brett J.¹,Craig Stephen R.¹,Gaus Hans J.¹,Scozzari Anthony N.¹,Cole Douglas L.¹,Ravikumar Vasulinga T.¹

Affiliation:

1. Isis Pharmaceuticals, 2290 Faraday Avenue, Carlsbad California 92008, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op990077b

Reference46 articles.

1. An Overview of Progress in Antisense Therapeutics

2. Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

Cited by 50 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. 2′-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity;Nucleic Acid Therapeutics;2022-06-01

2. Green Synthesis of Thiuram Disulfides with CO2 as an Acid Agent for Sustainable Development;Industrial & Engineering Chemistry Research;2018-11-15

3. A Versatile and Convenient Synthesis of 34 S-Labeled Phosphorothioate Oligonucleotides;ChemBioChem;2018-09-13

4. Solid-Phase Synthesis of Phosphorothioate Oligonucleotides Using Sulfurization Byproducts for in Situ Capping;The Journal of Organic Chemistry;2018-09-04

5. 34S: A New Opportunity for the Efficient Synthesis of Stable Isotope Labeled Compounds;Chemistry - A European Journal;2018-04-26