Oxidative N-Dealkylation of p-Cyclopropyl-N,N-dimethylaniline. A Substituent Effect on a Radical-Clock Reaction Rationalized by Ab Initio Calculations on Radical Cation Intermediates-Reference-Cited by-同舟云学术

Oxidative N-Dealkylation of p-Cyclopropyl-N,N-dimethylaniline. A Substituent Effect on a Radical-Clock Reaction Rationalized by Ab Initio Calculations on Radical Cation Intermediates

Published:1997-11-01 Issue:23 Volume:62 Page:8227-8230
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Chen Hao¹,de Groot Marcel J.¹,Vermeulen Nico P. E.¹,Hanzlik Robert P.¹

Affiliation:

1. Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045-2506, and Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo9709209

Reference55 articles.

1. Editorial

2. Kinetic deuterium isotope effects on the N-demethylation of tertiary amides by cytochrome P-450.

3. N-Dealkylation of tertiary amides by cytochrome P-450

4. The microsomal dealkylation of N,N-dialkylbenzamides

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