Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C–C Bond Cleavage

Author:

Cao Zhi-Qin12,Wang Gao-Qian2,Luo Rui2,Gao Yao-Hui3,Lv Jian-Ming2,Qin Sheng-Ying4,Chen Guo-Dong2,Awakawa Takayoshi56,Bao Xue-Feng2,Mei Qing-Hua7,Yao Xin-Sheng23ORCID,Hu Dan2ORCID,Abe Ikuro5ORCID,Gao Hao2ORCID

Affiliation:

1. Department of Pharmacy, Guangdong Second Provincial General Hospital, Integrated Chinese and Western Medicine Postdoctoral Research Station, School of Medicine, Jinan University, Guangzhou 510317, China

2. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou 510632, China

3. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

4. Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China

5. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

6. RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan

7. Department of Pharmacy, Guangdong Second Provincial General Hospital, Guangzhou 510317, China

Funder

National Key Research and Development Program of China

Basic and Applied Basic Research Foundation of Guangdong Province

Science Fund for Distinguished Young Scholars of Guangdong Province

Guangzhou Municipal Science and Technology Bureau

Guangdong Provincial Pearl River Talents Program

Japan Society for the Promotion of Science

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Guangdong International Science and Technology Cooperation Base

Innovative and Research Teams Project of Guangdong Higher Education Institution

Publisher

American Chemical Society (ACS)

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