Comparison of Information-Dependent Acquisition, SWATH, and MSAll Techniques in Metabolite Identification Study Employing Ultrahigh-Performance Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry

Author:

Zhu Xiaochun1,Chen Yuping1,Subramanian Raju1

Affiliation:

1. Pharmacokinetics and Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Reference35 articles.

1. Guidance for Industry: Safety Testing of Drug Metabolites, 2008. Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration (FDA) Web site.http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm079266.pdf(accessed Sept 20, 2013).

2. ICH Guidance on Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals M3 (Revision 2), 2009. ICH Web site.http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Multidisciplinary/M3_R2/Step4/M3_R2__Guideline.pdf(accessed Sept 20, 2013).

3. M3(R2) Guideline: Guidance on Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals. Questions & Answers (R2), 2012. ICH Web site.http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Multidisciplinary/M3_R2/Q_As/M3_R2_Q_A_R2_Step4.pdf(accessed Sept 20, 2013).

4. Analytical strategies for identifying drug metabolites

5. Application of Mass Spectrometry for Metabolite Identification

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