Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion

Author:

Wang Bin1,Tang Maoping1,Chen Qijing1,Ho William,Teng Yilong1,Xiong Xiaojian1,Jia Zhitong1,Li Xiuling2,Xu XiaoyangORCID,Zhang Xue-Qing1ORCID

Affiliation:

1. Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai 200240, China

2. Shanghai Institute of Biological Products Co., Ltd., Shanghai 200051, China

Funder

Natural Science Foundation of Shanghai Municipality

National Key Research and Development Program of China

National Center of Technology Innovation for Biopharmaceuticals, Ministry of Science and Technology of the People's Republic of China

Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Shanghai Jiao Tong University

Publisher

American Chemical Society (ACS)

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