Silicon Ether Ionizable Lipids Enable Potent mRNA Lipid Nanoparticles with Rapid Tissue Clearance-Reference-Cited by-同舟云学术

Silicon Ether Ionizable Lipids Enable Potent mRNA Lipid Nanoparticles with Rapid Tissue Clearance

Published:2024-04-03 Issue:15 Volume:18 Page:10374-10387
ISSN:1936-0851
Container-title:ACS Nano
language:en
Short-container-title:ACS Nano

Author:

Holland Richard¹^ORCID,Lam Kieu¹^ORCID,Jeng Sunny¹^ORCID,McClintock Kevin¹^ORCID,Palmer Lorne¹^ORCID,Schreiner Petra¹^ORCID,Wood Mark¹^ORCID,Zhao Wenchen¹^ORCID,Heyes James¹^ORCID

Affiliation:

1. Genevant Science Corporation, Unit 155-887 Great Northern Way, Vancouver, British Columbia V5T 4T5, Canada

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsnano.3c09028

Reference50 articles.

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3. Lipid nanoparticles for nucleic acid delivery: Current perspectives

4. European Medicines Agency. Assessment Report: Onpattro (patisiran), 2018. www.ema.europa.eu/en/documents/assessment-report/onpattro-epar-public-assessment-report_.pdf (accessed June 2023).

5. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

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