A MnO2 Nanoparticle-Dotted Hydrogel Promotes Spinal Cord Repair via Regulating Reactive Oxygen Species Microenvironment and Synergizing with Mesenchymal Stem Cells

Author:

Li Liming12,Xiao Bing13,Mu Jiafu1,Zhang Yu1,Zhang Chenyang1,Cao Hongcui4,Chen Rongjun5ORCID,Patra Hirak Kumar6ORCID,Yang Bo1,Feng Shiqing78,Tabata Yasuhiko9,Slater Nigel K. H.6,Tang Jianbin3ORCID,Shen Youqing3ORCID,Gao Jianqing12ORCID

Affiliation:

1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

2. Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou 310058, China

3. Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China

4. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

5. Department of Chemical Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom

6. Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB2 0SP, United Kingdom

7. Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, China

8. Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin 300052, China

9. Department of Regeneration Science and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8501, Japan

Funder

Zhejiang University

Ministry of Education of the People's Republic of China

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Central Committee of the Communist Party of China

Zhejiang Province

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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