mRNA-Laden Lipid-Nanoparticle-Enabled in Situ CAR-Macrophage Engineering for the Eradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model

Author:

Tang Chunwei1,Jing Weiqiang2,Han Kun1,Yang Zhenmei1,Zhang Shengchang1,Liu Miaoyan1,Zhang Jing1,Zhao Xiaotian1,Liu Ying1,Shi Chongdeng1,Chai Qihao1,Li Ziyang1,Han Maosen1,Wang Yan1,Fu Zhipeng1,Zheng Zuolin1,Zhao Kun1,Sun Peng3,Zhu Danqing4ORCID,Chen Chen5,Zhang Daizhou6,Li Dawei6,Ni Shilei7ORCID,Li Tao8,Cui Jiwei9ORCID,Jiang Xinyi1ORCID

Affiliation:

1. NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China

2. Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, 107 Cultural West Road, Jinan, Shandong Province 250012, China

3. Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China

4. Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, 4572A Academic Building, Clear Water Bay, Kowloon, Hong Kong 999077, China

5. Key Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College of Shandong University, Jinan, Shandong Province 250012, China

6. Shandong Academy of Pharmaceutical Sciences, Jinan, Shandong Province 250101, China

7. Department of Neurosurgery, Qilu Hospital and Institute of Brain and Brain-Inspired Science, Cheeloo College of Medicine, Shandong University, 107 Cultural West Road, Jinan, Shandong Province 250012, China

8. Department of General Surgery, Qilu Hospital, Shandong University, 107 Cultural West Road, Jinan, Shandong Province 250012, China

9. Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong Province 250100, China

Funder

National Natural Science Foundation of China

International Cooperation and Exchange Programme

Key Technology Research and Development Program of Shandong Province

Fundamental Research Funds of Shandong Province

Publisher

American Chemical Society (ACS)

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