Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking

Author:

Sofias Alexandros Marios123ORCID,Toner Yohana C.2,Meerwaldt Anu E.24,van Leent Mandy M. T.25,Soultanidis Georgios2,Elschot Mattijs16,Gonai Haruki2,Grendstad Kristin7,Flobak Åsmund89,Neckmann Ulrike1011,Wolowczyk Camilla1011,Fisher Elizabeth L.2,Reiner Thomas1213ORCID,Davies Catharina de Lange7,Bjørkøy Geir91011,Teunissen Abraham J. P.2ORCID,Ochando Jordi1415,Pérez-Medina Carlos216,Mulder Willem J. M.2517ORCID,Hak Sjoerd118

Affiliation:

1. Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7030 Trondheim, Norway

2. BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

3. Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany

4. Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands

5. Department of Medical Biochemistry, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands

6. Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway

7. Department of Physics, Faculty of Natural Sciences, Norwegian University of Science and Technology (NTNU), 7034 Trondheim, Norway

8. The Cancer Clinic, St. Olav’s University Hospital, 7030 Trondheim, Norway

9. Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7030 Trondheim, Norway

10. Department of Biomedical Laboratory Science, Faculty of Natural Sciences, Norwegian University of Science and Technology (NTNU), 7030 Trondheim, Norway

11. Centre of Molecular Inflammation Research (CEMIR), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7030 Trondheim, Norway

12. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

13. Department of Radiology, Weill Cornell Medical College, New York, New York 10065, United States

14. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

15. Transplant Immunology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28220 Madrid, Spain

16. Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain

17. Laboratory of Chemical Biology, Department of Biochemical Engineering, Eindhoven University of Technology, 5612 AP Eindhoven, The Netherlands

18. Department of Biotechnology and Nanomedicine, SINTEF Industry, 7034 Trondheim, Norway

Funder

National Cancer Institute

Norges Forskningsr?d

Helse Midt-Norge

American Heart Association

Trond Mohn Foundation

Troms? Research Foundation

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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