Structure–Activity Relationships of 4-Position Diamine Quinoline Methanols as Intermittent Preventative Treatment (IPT) against Plasmodium falciparum-Reference-Cited by-同舟云学术

Structure–Activity Relationships of 4-Position Diamine Quinoline Methanols as Intermittent Preventative Treatment (IPT) against Plasmodium falciparum

Published:2011-08-22 Issue:18 Volume:54 Page:6277-6285
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Milner Erin¹,Gardner Sean¹,Moon Jay¹,Grauer Kristina¹,Auschwitz Jennifer¹,Bathurst Ian²,Caridha Diana¹,Gerena Lucia¹,Gettayacamin Montip³,Johnson Jacob¹,Kozar Michael¹,Lee Patricia¹,Leed Susan¹,Li Qigui¹,McCalmont William¹,Melendez Victor¹,Roncal Norma¹,Sciotti Richard¹,Smith Bryan¹,Sousa Jason¹,Tungtaeng Anchalee³,Wipf Peter⁴,Dow Geoffrey¹

Affiliation:

1. Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States

2. Medicines for Malaria Venture, International Center Cointrin, Route de Pre-Bois 20, P.O. Box 1826, CH-1215 Geneva 15, Switzerland

3. United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

4. Department of Chemistry, University of Pittsburgh, Parkman Avenue, CSC 1301, Pittsburgh, Pennsylvania 15260, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200647u

Reference16 articles.

1. Intermittent Treatment for the Prevention of Malaria during Pregnancy in Benin: A Randomized, Open‐Label Equivalence Trial Comparing Sulfadoxine‐Pyrimethamine with Mefloquine

2. Intermittent preventive treatment of infants with mefloquine reduces risk of clinical malaria in areas of moderate malaria transmission and high resistance to sulphadoxine-pyrimethamine, but safety and tolerability issues need consideration

3. Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

4. Structure–activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum

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