Toward Understanding Molecular Heterogeneity of Polysorbates by Application of Liquid Chromatography–Mass Spectrometry with Computer-Aided Data Analysis
Author:
Affiliation:
1. Protein Analytical Chemistry Department, and ‡Late Stage Pharmaceutical and Process Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ac2005789
Reference28 articles.
1. A thermodynamic analysis of the binding interaction between polysorbate 20 and 80 with human serum albumins and immunoglobulins: A contribution to understand colloidal protein stabilisation
2. Polysorbate 20 prevents the precipitation of a monoclonal antibody during shear
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4. Antibody Structure, Instability, and Formulation
5. Protein aggregation and its inhibition in biopharmaceutics
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