Product Deuterium Isotope Effects for Orotidine 5′-Monophosphate Decarboxylase: Effect of Changing Substrate and Enzyme Structure on the Partitioning of the Vinyl Carbanion Reaction Intermediate-Reference-Cited by-同舟云学术

Product Deuterium Isotope Effects for Orotidine 5′-Monophosphate Decarboxylase: Effect of Changing Substrate and Enzyme Structure on the Partitioning of the Vinyl Carbanion Reaction Intermediate

Published:2010-05-04 Issue:20 Volume:132 Page:7018-7024
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Toth Krisztina¹,Amyes Tina L.¹,Wood Bryant M.¹,Chan Kui¹,Gerlt John A.¹,Richard John P.¹

Affiliation:

1. Department of Chemistry, University at Buffalo, Buffalo, New York 14260, and Departments of Biochemistry and Chemistry, University of Illinois, Urbana, Illinois 61801

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja102408k

Reference46 articles.

1. OMP decarboxylase—An enigma persists

2. Catalytic Proficiency: The Unusual Case of OMP Decarboxylase

3. A Proficient Enzyme

4. Activation of Orotidine 5‘-Monophosphate Decarboxylase by Phosphite Dianion: The Whole Substrate is the Sum of Two Parts

5. Phosphate Binding Energy and Catalysis by Small and Large Molecules

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