Analysis of Human Cytochrome P450 2C8 Substrate Specificity Using a Substrate Pharmacophore and Site-Directed Mutants-Reference-Cited by-同舟云学术

Analysis of Human Cytochrome P450 2C8 Substrate Specificity Using a Substrate Pharmacophore and Site-Directed Mutants

Published:2004-11-18 Issue:49 Volume:43 Page:15379-15392
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Melet Armelle¹,Marques-Soares Cristina¹,Schoch Guillaume A.¹,Macherey Anne-Christine¹,Jaouen Maryse¹,Dansette Patrick M.¹,Sari Marie-Agnès¹,Johnson Eric F.¹,Mansuy Daniel¹

Affiliation:

1. Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris 5, 45 Rue des Saints-Pères, 75270 Paris Cedex 06, France, and Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM-255, La Jolla, California 92037

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi0489309

Reference78 articles.

1. Cytochrome P450

2. Molecular Cloning, Expression and Characterization of an Endogenous Human Cytochrome P450 Arachidonic Acid Epoxygenase Isoform

3. Gene structure ofCYP2C8 and extrahepatic distribution of the human CYP2Cs

Cited by 41 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Novel cytochrome P450 2C119 enzymes in cynomolgus and rhesus macaques metabolize progesterone, diclofenac, and omeprazole;Drug Metabolism and Disposition;2023-12-15

2. Functional Characterization of Allelic Variations of Human Cytochrome P450 2C8 (V181I, I244V, I331T, and L361F);International Journal of Molecular Sciences;2023-04-28

3. Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges;Biomolecules;2022-09-01

4. CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate;Drug Metabolism and Disposition;2021-12-20

5. Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310;Journal of Medicinal Chemistry;2021-03-08