Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints-Reference-Cited by-同舟云学术

Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints

Published:2013-10-31 Issue:45 Volume:117 Page:14029-14038
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Clark Nicholas J.¹,Zhang Hailiang²,Krueger Susan¹,Lee Hyo Jin³,Ketchem Randal R.⁴,Kerwin Bruce³,Kanapuram Sekhar R.³,Treuheit Michael J.⁴,McAuley Arnold³,Curtis Joseph E.¹

Affiliation:

1. NIST Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, Maryland 20899, United States

2. Institute for Research and Applied Physics, University of Maryland, College Park, Maryland 20742, United States

3. Department of Drug Product Development, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

4. Therapeutic Discovery and Department of Drug Product Development, Amgen Inc., 1201 Amgen Court West, Seattle, Washington 98119, United States

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp408710r

Reference48 articles.

1. Gross Conformation of Rabbit 7 S γ-Immunoglobulin and Its Papain-cleaved Fragments

2. Electron microscopic evidence for the axial rotation and inter-domain flexibility of the fab regions of immunoglobulin G

3. Direct demonstration of multiple VH allotopes on rabbit Ig molecules: allotope characteristics and Fab arm rotational flexibility revealed by immunoelectron microscopy

4. Concerning the axial rotational flexibility of the Fab regions of immunoglobulin G

5. Genetically engineered immunoglobulins reveal structural features controlling segmental flexibility.

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