Identification of Potent and Selective Hydantoin Inhibitors of Aggrecanase-1 and Aggrecanase-2 That Are Efficacious in Both Chemical and Surgical Models of Osteoarthritis-Reference-Cited by-同舟云学术

Identification of Potent and Selective Hydantoin Inhibitors of Aggrecanase-1 and Aggrecanase-2 That Are Efficacious in Both Chemical and Surgical Models of Osteoarthritis

Published:2014-12-05 Issue:24 Volume:57 Page:10476-10485
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Durham Timothy B.¹,Klimkowski Valentine J.¹,Rito Christopher J.¹,Marimuthu Jothirajah¹,Toth James L.¹,Liu Chin¹,Durbin Jim D.¹,Stout Stephanie L.¹,Adams Lisa¹,Swearingen Craig¹,Lin Chaohua¹,Chambers Mark G.¹,Thirunavukkarasu Kannan¹,Wiley Michael R.¹

Affiliation:

1. Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501522n

Reference32 articles.

1. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II

2. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data

3. The Global Economic Cost of Osteoarthritis: How the UK Compares

4. Transynovial exchange of small molecules in normal human subjects

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