Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships-Reference-Cited by-同舟云学术

Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships

Published:2009-07-09 Issue:15 Volume:52 Page:4640-4649
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhao Chen¹,Sun Minghua¹,Bennani Youssef L.¹,Miller Thomas R.¹,Witte David G.¹,Esbenshade Timothy A.¹,Wetter Jill¹,Marsh Kennan C.¹,Hancock Arthur A.¹,Brioni Jorge D.¹,Cowart Marlon D.¹

Affiliation:

1. Department of Neuroscience Research, Global Pharmaceutical Research Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6123

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900480x

Reference30 articles.

1. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

2. Cloning and Functional Expression of the Human Histamine H3Receptor

3. Modulation of neurotransmitter releaseviahistamine H3heteroreceptors

4. High constitutive activity of native H3 receptors regulates histamine neurons in brain

5. The physiology of brain histamine

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