3,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure−Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds†PDB code of 2Z with PDK1: 3HRF.-Reference-Cited by-同舟云学术

3,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure−Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds†PDB code of 2Z with PDK1: 3HRF.

Published:2009-07-17 Issue:15 Volume:52 Page:4683-4693
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Stroba Adriana¹,Schaeffer Francis²,Hindie Valerie³,Lopez-Garcia Laura³,Adrian Iris³,Fröhner Wolfgang¹,Hartmann Rolf W.¹,Biondi Ricardo M.³,Engel Matthias¹

Affiliation:

1. Pharmaceutical and Medicinal Chemistry, Saarland University, P.O. Box 151150, D-66041 Saarbrücken, Germany

2. Unité de Biochimie Structurale (CNRS-URA 2185), Institut Pasteur, F-75724 Paris, France

3. Department of Internal Medicine I, University of Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9001499

Reference42 articles.

1. Protein kinases — the major drug targets of the twenty-first century?