Design, Synthesis, and Biological Evaluation of (E)-N-Aryl-2-arylethenesulfonamide Analogues as Potent and Orally Bioavailable Microtubule-Targeted Anticancer Agents

Author:

Reddy M. V. Ramana1,Mallireddigari Muralidhar R.2,Pallela Venkat R.2,Cosenza Stephen C.1,Billa Vinay K.1,Akula Balaiah2,Subbaiah D. R. C. Venkata1,Bharathi E. Vijaya1,Padgaonkar Amol1,Lv Hua3,Gallo James M.3,Reddy E. Premkumar1

Affiliation:

1. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, New York 10029-6514, United States

2. Department of Medicinal Chemistry, Onconova Therapeutics Inc., 375 Pheasant Run, Newtown, Pennsylvania 18940-3423, United States

3. Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, New York 10029-6514, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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