1. Graduate School of Environmental Earth Science and Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0810, Japan, Graduate Course for Regulation of Biological Signals, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan, Department of Dermatology, School of Medicine, Chiba University, Chiba 260-8670, Japan, and Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892-4370