Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate, Part 1: Improving the Pharmacokinetic Profile Using the Structure−Property Relationship-Reference-Cited by-同舟云学术

Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate, Part 1: Improving the Pharmacokinetic Profile Using the Structure−Property Relationship

Published:2007-08-28 Issue:19 Volume:50 Page:4572-4584
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bonfanti Jean-François¹,Doublet Frédéric¹,Fortin Jérôme¹,Lacrampe Jean¹,Guillemont Jérôme¹,Muller Philippe¹,Queguiner Laurence¹,Arnoult Eric¹,Gevers Tom¹,Janssens Peggy¹,Szel Heidi¹,Willebrords Rudy¹,Timmerman Philip¹,Wuyts Koen¹,Janssens Frans¹,Sommen Cois¹,Wigerinck Piet¹,Andries Koen¹

Affiliation:

1. Johnson & Johnson Pharmaceutical Research and Development, Medicinal Chemistry Department, Campus de Maigremont BP315, F-27106 Val de Reuil, France, Johnson & Johnson Pharmaceutical Research and Development, Antimicrobial Research Department, Turnhoutseweg 30, B-2340 Beerse, Belgium, Johnson & Johnson Pharmaceutical Research and Development, ADME-Tox & Bioanalysis Department, Turnhoutseweg 30, B-2340 Beerse, Belgium, Johnson & Johnson Pharmaceutical Research and Development, Medicinal Chemistry...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070143x

Reference20 articles.

1. Substituted benzimidazoles with nanomolar activity against respiratory syncytial virus

2. Severe Respiratory Syncytial Virus Bronchiolitis in Infancy and Asthma and Allergy at Age 13

3. Asma y virus respiratorio sincitial. Nuevas oportunidades de intervención terapéutica

Cited by 41 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Regioselective N-alkylation of 2-amino-azoles with alcohols for the synthesis of 2-N-(alkylamino)azoles catalyzed by a ruthenium complex bearing a functional ligand;Journal of Catalysis;2023-10

2. Identification and evaluation of a novel tribenzamide derivative as an inhibitor targeting the entry of the respiratory syncytial virus;Antiviral Research;2023-03

3. Design, synthesis, and biological activity studies on benzimidazole derivatives targeting myeloperoxidase;European Journal of Medicinal Chemistry;2023-02

4. Catalyst-free aza-Michael addition of azoles to 3-hydroxypyridine-based quinone methides;Tetrahedron;2023-01

5. Small-Molecule Inhibition of Viral Fusion Glycoproteins;Annual Review of Virology;2021-09-29