Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial Therapeutics

Author:

Keough Dianne T.1,Hocková Dana2,Holý Antonín2,Naesens Lieve M. J.3,Skinner-Adams Tina S.4,Jersey John de1,Guddat Luke W.1

Affiliation:

1. The School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072 QLD, Australia

2. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i. Flemingovo nam. 2, CZ-166 10 Prague 6, Czech Republic

3. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

4. Malaria Biology Laboratory, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Brisbane, 4029 QLD, Australia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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