1. Institute of Biomaterials and Biomedical Engineering and The Terrence Donnelly Centre for Cellular and Molecular Research, Institute of Medical Sciences and the McLaughlin Centre for Molecular Medicine, Department of Materials Science, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada, and McLaughlin-Rotman Centre for Global Health, Tropical Disease Unit, UHNToronto General Hospital, 190 Elizabeth Street, Toronto, Ontario M5M 1M1, Canada