Structural Insight into the Self-Assembly of a Pharmaceutically Optimized Insulin Analogue Obtained by Small-Angle X-ray Scattering-Reference-Cited by-同舟云学术

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Structural Insight into the Self-Assembly of a Pharmaceutically Optimized Insulin Analogue Obtained by Small-Angle X-ray Scattering

Published:2020-06-24 Issue:8 Volume:17 Page:2809-2820
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Dreyer Lasse Sander¹^ORCID,Nygaard Jesper¹,Malik Leila²,Hoeg-Jensen Thomas³^ORCID,Høiberg-Nielsen Rasmus⁴,Arleth Lise¹^ORCID

Affiliation:

1. Niels Bohr Institute, Faculty of Science, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark

2. Department of Chemistry, Faculty of Science, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark

3. Novo Nordisk A/S, Research Chemistry, Novo Nordisk Park H5.S.05, 2760 Måløv, Denmark

4. Novo Nordisk A/S, Diabetes Biophysics, Novo Nordisk Park G8S.439, 2760 Måløv, Denmark

Funder

Innovationsfonden

Lundbeckfonden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c00112

Reference36 articles.

1. WHO, Diabetes Fact Sheet. http://www.who.int/mediacentre/factsheets/fs312/en/, 2018 (accessed Oct 24, 2019).

2. Monomeric Insulins and Their Experimental and Clinical Implications

3. Molecular variants and derivatives of insulin for improved glycemic control in diabetes

4. Hoeg-Jensen, T. In Peptide and Protein Design for Biopharmaceutical Applications; Jensen, K. J., Ed. John Wiley & Sons, Ltd, 2009; pp 249–286.

5. 3: Preventing complications of diabetes

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1. Anisotropic protein-protein interactions in dilute and concentrated solutions;Journal of Colloid and Interface Science;2023-01

2. SAXS Reveals the Stabilization Effects of Modified Sugars on Model Proteins;Life;2022-01-15

3. Oligomerization of Pharmaceutically Relevant Insulin Analogues for Varying Concentration and Salinity Revealed by Small-Angle X-ray Scattering;Molecular Pharmaceutics;2021-08-05

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