Evaluation of Anti-LGR5 Antibodies by ImmunoPET for Imaging Colorectal Tumors and Development of Antibody–Drug Conjugates
Author:
Affiliation:
1. Wntrix, Inc., Houston, Texas 77021, United States
Funder
John S. Dunn Foundation
Welch Foundation
Cancer Prevention and Research Institute of Texas
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b00275
Reference33 articles.
1. LGR5-Targeted Antibody–Drug Conjugate Eradicates Gastrointestinal Tumors and Prevents Recurrence
2. Targeting LGR5 + cells with an antibody-drug conjugate for the treatment of colon cancer
3. Leucine-rich repeat-containing G-protein-coupled receptor 5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer
4. Overexpression of orphan G-protein–coupled receptor, Gpr49, in human hepatocellular carcinomas with β-catenin mutations
5. Identification and Cloning of an Orphan G Protein-Coupled Receptor of the Glycoprotein Hormone Receptor Subfamily
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3. Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells;Molecular Cancer Therapeutics;2023-03-15
4. Exploiting the Receptor-Binding Domains of R-Spondin 1 to Target Leucine-Rich Repeat-Containin G-Coupled Protein Receptor 5-Expressing Stem Cells in Ovarian Cancer;Journal of Pharmacology and Experimental Therapeutics;2023-02-27
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