A Silk-Based Platform to Stabilize Phenylalanine Ammonia-lyase for Orally Administered Enzyme Replacement Therapy-Reference-Cited by-同舟云学术

A Silk-Based Platform to Stabilize Phenylalanine Ammonia-lyase for Orally Administered Enzyme Replacement Therapy

Published:2022-07-21 Issue:12 Volume:19 Page:4625-4630
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

d’Amone Luciana¹^ORCID,Trivedi Vikas D.²³^ORCID,Nair Nikhil U.²^ORCID,Omenetto Fiorenzo G.¹⁴⁵⁶^ORCID

Affiliation:

1. Silklab, Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, United States

2. Department of Chemical & Biological Engineering, Tufts University, Medford, Massachusetts 02155, United States

3. Department of Structural Biology and Center for Data Driven Discovery, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105-3678, United States

4. Department of Electrical and Computer Engineering, Tufts University, Medford, Massachusetts 02155, United States

5. Department of Physics, Tufts University, Medford, Massachusetts 02155, United States

6. Laboratory for Living Devices, Tufts University, Medford, Massachusetts 02155, United States

Funder

National Institute of Child Health and Human Development

Office of Naval Research

Tufts University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.2c00512

Reference31 articles.

1. The Genetic Landscape and Epidemiology of Phenylketonuria

2. Phenylketonuria

3. A Comprehensive Review of Pegvaliase, an Enzyme Substitution Therapy for the Treatment of Phenylketonuria

4. Phenylalanine ammonia lyase (PAL): From discovery to enzyme substitution therapy for phenylketonuria

5. A New Theory of Enterorecirculation of Amino Acids and its use for Depleting Unwanted Amino Acids Using Oral Enzyme-Artificial Cells, as in Removing Phenylalanine in Phenylketonuria

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