Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters

Author:

Caetano-Pinto Pedro1,Jamalpoor Amer1,Ham Janneke2,Goumenou Anastasia1,Mommersteeg Monique3,Pijnenburg Dirk3,Ruijtenbeek Rob3,Sanchez-Romero Natalia14,van Zelst Bertrand5,Heil Sandra G.5,Jansen Jitske1,Wilmer Martijn J.6,van Herpen Carla M. L.2,Masereeuw Rosalinde1ORCID

Affiliation:

1. Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands

2. Department of Oncology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

3. PamGene, 5211 HH ‘s-Hertogenbosch, The Netherlands

4. Centro Investigación Biomédica de Aragón (CIBA), 50009 Zaragoza, Spain

5. Department of Clinical Chemistry, ErasmusMC, 3015 CE Rotterdam, The Netherlands

6. Department of Pharmacology and Toxicology, Radboud Institute of Molecular Life Sciences, Radboudumc, 6500 HB Nijmegen, The Netherlands

Funder

Nierstichting

Seventh Framework Programme

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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