Interpreting the Physicochemical Meaning of a Molecular Descriptor Which Is Predictive of Amorphous Solid Dispersion Formation in Polyvinylpyrrolidone Vinyl Acetate-Reference-Cited by-同舟云学术

Interpreting the Physicochemical Meaning of a Molecular Descriptor Which Is Predictive of Amorphous Solid Dispersion Formation in Polyvinylpyrrolidone Vinyl Acetate

Published:2021-12-21 Issue:1 Volume:19 Page:303-317
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

DeBoyace Kevin¹,Bookwala Mustafa¹,Buckner Ira S.¹,Zhou Deliang²^ORCID,Wildfong Peter L. D.¹^ORCID

Affiliation:

1. School of Pharmacy and Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States

2. Drug Product Development, Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00783

Reference41 articles.

1. Theoretical and Practical Approaches for Prediction of Drug–Polymer Miscibility and Solubility

2. Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility