Development of Fibroblast Activation Protein Inhibitor-Based Dimeric Radiotracers with Improved Tumor Retention and Antitumor Efficacy

Author:

Zhao Liang12,Chen Jianhao12,Pang Yizhen12,Fang Jianyang3,Fu Kaili4,Meng Lingxin3,Zhang Xianzhong3ORCID,Guo Zhide3,Wu Hua1,Sun Long1,Su Guoqiang5,Lin Qin2,Chen Haojun1ORCID

Affiliation:

1. Department of Nuclear Medicine and Minnan PET Center, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, China

2. Department of Radiation Oncology, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, China

3. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China

4. Department of Oncology, The Second Affiliated Hospital of Jiaxing University, Jiaxing 310009, China

5. Department of Colorectal Tumor Surgery, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, Fujian, China

Funder

Natural Science Foundation of Fujian Province

National Natural Science Foundation of China

Key Medical and Health Projects in Xiamen

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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