Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab′ Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity-Reference-Cited by-同舟云学术

Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab′ Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity

Published:2016-02-29 Issue:4 Volume:13 Page:1229-1241
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Chan Linda J.¹,Ascher David B.²,Yadav Rajbharan¹,Bulitta Jürgen B.¹³,Williams Charlotte C.⁴,Porter Christopher J. H.¹,Landersdorfer Cornelia B.¹,Kaminskas Lisa M.¹

Affiliation:

1. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

2. Department of Biochemistry, University of Cambridge, Sanger Building, Downing Site, Cambridge, CB2 1GA, U.K.

3. Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida 32816, United States

4. CSIRO Materials Science and Engineering, 343 Royal Parade, Parkville, Victoria 3052, Australia

Funder

National Health and Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5b00749

Reference37 articles.

1. Development trends for human monoclonal antibody therapeutics

2. Therapeutic antibodies: successes, limitations and hopes for the future

3. PEGylated antibodies and antibody fragments for improved therapy: a review

4. Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

5. The Lymphatic System Plays a Major Role in the Intravenous and Subcutaneous Pharmacokinetics of Trastuzumab in Rats

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Prolonged delivery of HIV-1 vaccine nanoparticles from hydrogels;International Journal of Pharmaceutics;2024-05

2. Pegylation, a Successful Strategy to Address the Storage and Instability Problems of Blood Products: Review 2011-2021;Current Pharmaceutical Biotechnology;2024-02

3. Understanding the complementarity and plasticity of antibody–antigen interfaces;Bioinformatics;2023-06-29

4. Using Graph-Based Signatures to Guide Rational Antibody Engineering;Computer-Aided Antibody Design;2022-11-09

5. Structure–function relationships in polymeric multilayer capsules designed for cancer drug delivery;Biomaterials Science;2022