Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease

Published:2017-09-13 Issue:10 Volume:14 Page:3499-3511
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Xu Guoyan G.,Pagare Piyusha P.,Ghatge Mohini S.,Safo Ronni P.,Gazi Aheema¹,Chen Qiukan²,David Tanya^ORCID,Alabbas Alhumaidi B.,Musayev Faik N.,Venitz Jürgen,Zhang Yan^ORCID,Safo Martin K.^ORCID,Abdulmalik Osheiza²

Affiliation:

1. Department of Biology, School of Arts & Sciences, University of Richmond, Richmond, Virginia 23173, United States

2. Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States

Funder

U.S. Department of Health and Human Services

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b00553

Reference43 articles.

1. Abnormal human haemoglobins. III the chemical difference between normal and sickle cell haemoglobins

2. Sickle Cell Anemia, a Molecular Disease

3. The dual roles of red blood cells in tissue oxygen delivery: oxygen carriers and regulators of local blood flow

4. Sickle hemoglobin disturbs normal coupling among erythrocyte O2 content, glycolysis, and antioxidant capacity

5. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

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