1. Department of Pharmaceutical Sciences, University of Ferrara, I-44100 Ferrara, Italy, Department of Physiology and Pharmacology “Vittorio Erspamer”, University “La Sapienza”, I-00185 Rome, Italy, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy, Department of Toxicology, University of Cagliari, I-09124, Cagliari, Italy