Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity-Reference-Cited by-同舟云学术

Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity

Published:2010-06-30 Issue:15 Volume:53 Page:5690-5695
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chorell Erik¹,Pinkner Jerome S.²,Phan Gilles³,Edvinsson Sofie¹,Buelens Floris³,Remaut Han³⁴,Waksman Gabriel³,Hultgren Scott J.²,Almqvist Fredrik¹

Affiliation:

1. Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden

2. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110

3. Institute of Structural and Molecular Biology, University College London/Birkbeck, Malet Street, London WC1E 7HX, U.K.

4. Department of Cellular and Molecular Interactions, Laboratory for Structural and Molecular Microbiology, Structural Biology Brussels, Vrije Universiteit Brussel/VIB, 1050 Brussels, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100470t

Reference30 articles.

1. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

2. The biology and future prospects of antivirulence therapies

3. Targeting virulence: a new paradigm for antimicrobial therapy

4. Pilus Biogenesis via the Chaperone/Usher Pathway: An Integration of Structure and Function

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