Discovery of Novel, Potent, and Selective Small-Molecule CCR5 Antagonists as Anti-HIV-1 Agents: Synthesis and Biological Evaluation of Anilide Derivatives with a Quaternary Ammonium Moiety-Reference-Cited by-同舟云学术

Discovery of Novel, Potent, and Selective Small-Molecule CCR5 Antagonists as Anti-HIV-1 Agents: Synthesis and Biological Evaluation of Anilide Derivatives with a Quaternary Ammonium Moiety

Published:2000-04-21 Issue:10 Volume:43 Page:2049-2063
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shiraishi Mitsuru¹,Aramaki Yoshio¹,Seto Masaki¹,Imoto Hiroshi¹,Nishikawa Youichi¹,Kanzaki Naoyuki¹,Okamoto Mika¹,Sawada Hidekazu¹,Nishimura Osamu¹,Baba Masanori¹,Fujino Masahiko¹

Affiliation:

1. Pharmaceutical Research Division and Discovery Research Division, Takeda Chemical Industries, Ltd., 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan, and Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9906264

Reference27 articles.

1. HIV-1 Protease Inhibitors

2. HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

3. CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

4. Identification of a major co-receptor for primary isolates of HIV-1

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