Evaluation of Hydroxyimine as Cytochrome P450-Selective Prodrug Structure-Reference-Cited by-同舟云学术

Evaluation of Hydroxyimine as Cytochrome P450-Selective Prodrug Structure

Published:2006-01-13 Issue:3 Volume:49 Page:1207-1211
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kumpulainen Hanna¹,Mähönen Niina¹,Laitinen Marja-Leena¹,Jaurakkajärvi Marja¹,Raunio Hannu¹,Juvonen Risto O.¹,Vepsäläinen Jouko¹,Järvinen Tomi¹,Rautio Jarkko¹

Affiliation:

1. Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, FI-70211 Kuopio, Finland, Department of Pharmacology and Toxicology, University of Kuopio, PO Box 1627, FI-70211 Kuopio, Finland, and Department of Chemistry, University of Kuopio, PO Box 1627, FI-70211 Kuopio, Finland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0510124

Reference27 articles.

1. Prodrug research: futile or fertile?

2. Improved oral drug delivery: solubility limitations overcome by the use of prodrugs

3. Microsomal Cytochrome P450 Dependent Oxidation of N-Hydroxyguanidines, Amidoximes, and Ketoximes: Mechanism of the Oxidative Cleavage of Their CN(OH) Bond with Formation of Nitrogen Oxides

4. Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes

5. Human Extrahepatic Cytochromes P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts

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