Assessment of Additive/Nonadditive Effects in Structure−Activity Relationships: Implications for Iterative Drug Design-Reference-Cited by-同舟云学术

Assessment of Additive/Nonadditive Effects in Structure−Activity Relationships: Implications for Iterative Drug Design

Published:2008-11-14 Issue:23 Volume:51 Page:7552-7562
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Patel Yogendra¹,Gillet Valerie J.¹,Howe Trevor¹,Pastor Joaquin¹,Oyarzabal Julen¹,Willett Peter¹

Affiliation:

1. Department of Information Studies, University of Sheffield, Regent Court, 211 Portobello Street, Sheffield S1 4DP, United Kingdom, Department of Molecular Informatics, Johnson & Johnson Pharmaceutical R&D, Turnhoutseweg 30, 2340 Beerse, Belgium, Department of Medicinal Chemistry, Johnson & Johnson Pharmaceutical R&D, Jarama 75, 45007 Toledo, Spain, Department of Molecular Informatics, Johnson & Johnson Pharmaceutical R&D, Jarama 75, 45007 Toledo, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801070q

Reference49 articles.

1. How to escape the bottleneck of medicinal chemistry

2. Additivity Principles in Biochemistry

3. Molecular and biological constraints on ligand-binding affinity and specificity

4. On the attribution and additivity of binding energies

5. Fragment-Based Drug Discovery

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