Proposed Mechanism for the Reaction Catalyzed by a Diterpene Cyclase, Aphidicolan-16β-ol Synthase: Experimental Results on Biomimetic Cyclization and Examination of the Cyclization Pathway by ab Initio Calculations-Reference-Cited by-同舟云学术

Proposed Mechanism for the Reaction Catalyzed by a Diterpene Cyclase, Aphidicolan-16β-ol Synthase: Experimental Results on Biomimetic Cyclization and Examination of the Cyclization Pathway by ab Initio Calculations

Published:2002-07-16 Issue:31 Volume:124 Page:9145-9153
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Oikawa Hideaki¹,Nakamura Kensuke¹,Toshima Hiroaki¹,Toyomasu Tomonobu¹,Sassa Takeshi¹

Affiliation:

1. Contribution from the Department of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan, Institute of Medicinal Molecular Design Inc., 5-24-5 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Department of Bioresource Science, College of Agriculture, Ibaraki University, Ami-machi, Inashiki-gun, Ibaraki 300-0393, Japan, and Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja025830m

Reference46 articles.

1. Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α

2. Direct cloning and analysis of DNA sequences from a region of the Chinese hamster genome associated with aphidicolin-sensitive fragility

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