Solubilization of flavopiridol by pH control combined with cosolvents, surfactants, or complexants

Author:

Li Ping,Tabibi S.Esmail,Yalkowsky Samuel H.

Publisher

American Geophysical Union (AGU)

Subject

Pharmaceutical Science

Reference9 articles.

1. “The protein kinase C (PKC) inhibitors UCN‐01 and flavopiridol(Flavo) significantly enhance the cytotoxic effect of chemotherapy by promoting apoptosis in gastric and breast cancer cells;Schwartz;Proc. ASCO.,1996

2. Parenteral formulation of flavopiridol (NSC‐649890);Dannenfelser;PDA J. Pharm. Sci. Technol.,1995

3. Combined effect of complexation and pH on solubilization;Li;J. Pharm. Sci.,1998

4. Solubilization of ionized and un‐ionized flavopiridol by ethanol and polysorbate 20;Li;J. Pharm. Sci.,1999

5. Evaluation of intravenous flavopiridol formulations;Li;PDA J. Pharm. Sci. Technol.,1999

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