Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic Acid (BMS-587101)A Small Molecule Antagonist of Leukocyte Function Associated Antigen-1-Reference-Cited by-同舟云学术

Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic Acid (BMS-587101)A Small Molecule Antagonist of Leukocyte Function Associated Antigen-1

Published:2006-11-09 Issue:24 Volume:49 Page:6946-6949
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Potin Dominique¹,Launay Michele¹,Monatlik Francoise¹,Malabre Patrice¹,Fabreguettes Maud¹,Fouquet Andre¹,Maillet Magali¹,Nicolai Eric¹,Dorgeret Loïc¹,Chevallier François¹,Besse Dominique¹,Dufort Monique¹,Caussade François¹,Ahmad Syed Z.¹,Stetsko Dawn K.¹,Skala Stacey¹,Davis Patricia M.¹,Balimane Praveen¹,Patel Karishma¹,Yang Zheng¹,Marathe Punit¹,Postelneck Jennifer¹,Townsend Robert M.¹,Goldfarb Valentina¹,Sheriff Steven¹,Einspahr Howard¹,Kish Kevin¹,Malley Mary F.¹,DiMarco John D.¹,Gougoutas Jack Z.¹,Kadiyala Pathanjali¹,Cheney Daniel L.¹,Tejwani Ravindra W.¹,Murphy Denette K.¹,Mcintyre Kim W.¹,Yang Xiaoxia¹,Chao Sam¹,Leith Leslie¹,Xiao Zili¹,Mathur Arvind¹,Chen Bang-Chi¹,Wu Daugh-Rurng¹,Traeger Sarah C.¹,McKinnon Murray¹,Barrish Joel C.¹,Robl Jeffrey A.¹,Iwanowicz Edwin J.¹,Suchard Suzanne J.¹,Dhar T. G. Murali¹

Affiliation:

1. Cerep, 19 avenue du Quebec, 91951 Courtaboeuf cedex, France, and Bristol-Myers Squibb Pharmaceutical Research Institute, Post Office Box 4000, Princeton, New Jersey 08543

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0610806

Reference19 articles.

1. Mechanisms contributing to the activity of integrins on leukocytes

2. Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice

3. A Novel Targeted T-Cell Modulator, Efalizumab, for Plaque Psoriasis

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