Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents

Author:

Wang Mei-Juan1,Liu Ying-Qian1,Chang Ling-Chu23,Wang Chih-Ya4,Zhao Yong-Long1,Zhao Xiao-Bo1,Qian Keduo4,Nan Xiang1,Yang Liu5,Yang Xiao-Ming4,Hung Hsin-Yi23,Yang Jai-Sing6,Kuo Daih-Huang7,Goto Masuo4,Morris-Natschke Susan L.4,Pan Shiow-Lin8,Teng Che-Ming9,Kuo Sheng-Chu3,Wu Tian-Shung10,Wu Yang-Chang3,Lee Kuo-Hsiung34

Affiliation:

1. School of Pharmacy, Lanzhou University, Lanzhou 730000, PR China

2. Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan

3. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan

4. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States

5. Environmental and Municipal Engineering School, Lanzhou Jiaotong University, Lanzhou 730000, PR China

6. Department of Pharmacology, China Medical University, Taichung 404, Taiwan

7. Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan

8. Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan

9. Pharmacological Institute, College of Medicine, National Taiwan University, Taipei 10051, Taiwan

10. Department of Chemistry, National Cheng-Kung University, Tainan 701, Taiwan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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