Polyglutamine Solution-State Structural Propensity Is Repeat Length Dependent
Author:
Affiliation:
1. Department of Chemistry and Biochemistry, Center for Computational Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, United States
Funder
University of Pittsburgh
National Institute on Drug Abuse
Defense Threat Reduction Agency
Publisher
American Chemical Society (ACS)
Subject
Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.9b01433
Reference61 articles.
1. Trinucleotide Repeat Disorders
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3. Formation and Toxicity of Soluble Polyglutamine Oligomers in Living Cells
4. Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells
5. Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease
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