Botulinum Endopeptidase: SAXS Experiments and MD Simulations Reveal Extended Solution Structures That Account for Its Biochemical Properties
Author:
Affiliation:
1. Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, Massachusetts 02747, United States
2. Department of Chemistry, University of Massachusetts, Lowell, Massachusetts 01854, United States
Funder
Infinity Foundation
DOD
Publisher
American Chemical Society (ACS)
Subject
Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.0c02817
Reference51 articles.
1. Molecular Pharmacology of Botulinum Toxin and Tetanus Toxin
2. Botulinum Toxin as a Biological Weapon
3. The Botulinum Toxin as a Therapeutic Agent: Molecular Structure and Mechanism of Action in Motor and Sensory Systems
4. A novel role of C-terminus in introducing a functionally flexible structure critical for the biological activity of botulinum neurotoxin
5. Functional repair of motor endplates after botulinum neurotoxin type A poisoning: Biphasic switch of synaptic activity between nerve sprouts and their parent terminals
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