Hydrolysis of DFP and the Nerve Agent (S)-Sarin by DFPase Proceeds along Two Different Reaction Pathways: Implications for Engineering Bioscavengers-Reference-Cited by-同舟云学术

Hydrolysis of DFP and the Nerve Agent (S)-Sarin by DFPase Proceeds along Two Different Reaction Pathways: Implications for Engineering Bioscavengers

Published:2014-04-21 Issue:17 Volume:118 Page:4479-4489
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Wymore Troy¹²,Field Martin J.³,Langan Paul⁴,Smith Jeremy C.¹²,Parks Jerry M.¹

Affiliation:

1. UT/ORNL Center for Molecular Biophysics, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6309, United States

2. Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, United States

3. Institut de Biologie Structurale “Jean-Pierre Ebel”, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France

4. Center for Structural and Molecular Biology, Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6309, United States

Funder

National Institutes of Health

National Nuclear Security Administration

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp410422c

Reference68 articles.

1. Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes

2. Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: Reactivation involving flipping of the His447 ring to form a reactive Glu334–His447–oxime triad

3. First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

4. Stereochemistry and secondary reactions in the irreversible inhibition of serine hydrolases by organophosphorus compounds

5. Ageing and dealkylation of soman (pinacolylmethylphosphonofluoridate)-inactivated eel cholinesterase

Cited by 37 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The prediction of hydrolysis and biodegradation of organophosphorus-based chemical warfare agents (G-series and V-series) using toxicology in silico methods;Ecotoxicology and Environmental Safety;2024-03

2. Effective remediation and decontamination of organophosphorus compounds using enzymes: From rational design to potential applications;Science of The Total Environment;2023-04

3. A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness;Inhalation Toxicology;2022-11-17

4. Selective detection of F− ion and SO2 molecule: An experimental and DFT study;Journal of Molecular Liquids;2022-08

5. Bio-catalytic system of metallohydrolases for remediation of neurotoxin organophosphates and applications with a future vision;Journal of Inorganic Biochemistry;2022-06