Rationalizing PROTAC-Mediated Ternary Complex Formation Using Rosetta-Reference-Cited by-同舟云学术

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Rationalizing PROTAC-Mediated Ternary Complex Formation Using Rosetta

Published:2021-02-24 Issue:3 Volume:61 Page:1368-1382
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Bai Nan¹²,Miller Sven A.¹,Andrianov Grigorii V.¹³,Yates Max¹^ORCID,Kirubakaran Palani¹,Karanicolas John¹^ORCID

Affiliation:

1. Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, United States

2. Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, United States

3. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia

Funder

National Science Foundation

U.S. Department of Health and Human Services

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.0c01451

Reference82 articles.

1. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

2. RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

3. Viral Modulators of Cullin RING Ubiquitin Ligases: Culling the Host Defense

4. Identification of a Primary Target of Thalidomide Teratogenicity

5. Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

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