Mechanism-Based Rational Discovery and In Vitro Evaluation of Novel Microtubule Stabilizing Agents with Non-Taxol-Competitive Activity-Reference-Cited by-同舟云学术

Mechanism-Based Rational Discovery and In Vitro Evaluation of Novel Microtubule Stabilizing Agents with Non-Taxol-Competitive Activity

Published:2020-04-14 Issue:6 Volume:60 Page:3204-3213
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Zúñiga-Bustos Matías¹,Vásquez Pilar A.²,Jaña Gonzalo A.¹^ORCID,Guzmán José L.²,Alderete Joel B.³,Jiménez Verónica A.¹^ORCID

Affiliation:

1. Departamento de Ciencias Químicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Autopista Concepción-Talcahuano 7100, Talcahuano 4260000, Chile

2. Laboratory of Molecular Neurobiology, Department of Physiology, Faculty of Biological Sciences, University of Concepcion, Concepción 4070386, Chile

3. Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile

Funder

Comisi?n Nacional de Investigaci?n Cient?fica y Tecnol?gica

Fondo Nacional de Desarrollo Cient?fico y Tecnol?gico

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.9b01133

Reference39 articles.

1. Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton

2. Microtubules as a target for anticancer drugs

3. Structural Insights into Microtubule Function

4. Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option?

5. The Binding Sites of Microtubule-Stabilizing Agents

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