Unexpected Single-Ligand Occupancy and Negative Cooperativity in the SARS-CoV-2 Main Protease

Author:

Albani Simone12ORCID,Costanzi Elisa3,Hoang Gia Linh45ORCID,Kuzikov Maria67ORCID,Frings Marcus8ORCID,Ansari Narjes9ORCID,Demitri Nicola3ORCID,Nguyen Toan T.10ORCID,Rizzi Valerio11,Schulz Jörg B.4512,Bolm Carsten8ORCID,Zaliani Andrea136,Carloni Paolo14510ORCID,Storici Paola3ORCID,Rossetti Giulia1451214ORCID

Affiliation:

1. Institute for Neuroscience and Medicine (INM-9), Forschungszentrum Jülich, Jülich 52425, Germany

2. Faculty of Mathematics, Computer Science and Natural Sciences, RWTH Aachen, Aachen 52062, Germany

3. Elettra–Sincrotrone Trieste S.C.p.A., SS 14 – km 163, 5 in AREA Science Park, 34149 Basovizza, Trieste, Italy

4. JARA-Brain Institute Molecular Neuroscience and Neuroimaging, Research Center Jülich GmbH, Jülich 52425, Germany

5. RWTH Aachen University, Aachen 52056, Germany

6. Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Theodor Stern Kai 7, Frankfurt 60590, Germany

7. Constructor University, School of Science, Campus Ring 1, Bremen 28759, Germany

8. Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany

9. Atomistic Simulations, Italian Institute of Technology, Via Enrico Melen, 83, 16152 Genova, Italy

10. Key Laboratory for Multiscale Simulation of Complex Systems, and Department of Theoretical Physics, Faculty of Physics, University of Science, Vietnam National University – Hanoi, 334 Nguyen Trai Street, Thanh Xuan, Hanoi 11400, Vietnam

11. School of Pharmaceutical Sciences, University of Geneva, Rue Michel Servet 1, 1206 Genève, Switzerland

12. Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen 52074, Germany

13. Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Schnackenburgallee 114, Hamburg 22525, Germany

14. Jülich Supercomputing Center (JSC), Forschungszentrum Jülich, Jülich 52425, Germany

Funder

??i h?c Qu?c gia H? N?i

Helmholtz Association

Helmholtz European Partnering fundings for the project ?Innovative high-performance computing approaches for molecular neuromedicine?

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

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