QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni

Author:

Melo-Filho Cleber C.1,Dantas Rafael F.2,Braga Rodolpho C.1,Neves Bruno J.1,Senger Mario R.2,Valente Walter C. G.2,Rezende-Neto João M.2,Chaves Willian T.2,Muratov Eugene N.34,Paveley Ross A.5,Furnham Nicholas5,Kamentsky Lee6,Carpenter Anne E.6,Silva-Junior Floriano P.2,Andrade Carolina H.1

Affiliation:

1. LabMol−Laboratory for Molecular Modeling and Drug Design, Faculty of Pharmacy, Federal University of Goias, Rua 240, Qd.87, Goiania, GO 74605-510, Brazil

2. Laboratory of Experimental and Computational Biochemistry of Drugs, Oswaldo Cruz Institute, Av. Brasil, 4365, Rio de Janeiro, RJ 21040-900, Brazil

3. Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States

4. Department of Chemical Technology, Odessa National Polytechnic University, 1. Shevchenko Ave., Odessa, 65000, Ukraine

5. Department of Pathogen Molecular Biology & Department of Infection and Immunity, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom

6. Imaging Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, United States

Funder

Fundação de Amparo à Pesquisa do Estado de Goiás

Conselho Nacional de Desenvolvimento Científico e Tecnológico

National Institute of General Medical Sciences

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Reference87 articles.

1. Human schistosomiasis

2. World Health Organization. Schistosomiasishttp://www.who.int/mediacentre/factsheets/fs115/en/(accessed Jul 14, 2015) .

3. Schistosomiasis

4. Human schistosomiasis

5. World Health Organization. Progress Report 2001–2011 and Strategic Plan 2012–2020; Geneva, Switzerland, 2012.

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