Discovery of Novel 2,5-Dioxoimidazolidine-Based P2X7 Receptor Antagonists as Constrained Analogues of KN62-Reference-Cited by-同舟云学术

Discovery of Novel 2,5-Dioxoimidazolidine-Based P2X7 Receptor Antagonists as Constrained Analogues of KN62

Published:2015-02-23 Issue:5 Volume:58 Page:2114-2134
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Park Jin-Hee¹,Lee Ga-Eun²,Lee So-Deok¹,Hien Tran Thi,Kim Sujin¹,Yang Jin Won³,Cho Joong-Heui¹,Ko Hyojin¹,Lim Sung-Chul,Kim Yoon-Gyoon⁴,Kang Keon-Wook³,Kim Yong-Chul¹

Affiliation:

1. School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, Republic of Korea

2. Department of Pharmaceutical Industry, Korea Health Industry Development Institute(KHIDI), Chungcheongbuk-do 363-700, Republic of Korea

3. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea

4. College of Pharmacy, Dankook University, Cheonan 330-714, Republic of Korea

Funder

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500324g

Reference59 articles.

1. Nucleotide receptors

2. Crystal structure of the ATP-gated P2X4 ion channel in the closed state

3. The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )

4. Molecular Physiology of P2X Receptors

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